Aminoglycoside dosing: time to change

National survey of extended-interval aminoglycoside dosing.

A random sample survey of 500 acute care hospitals in the United States was conducted to evaluate the adoption of extended-interval aminoglycoside dosing (EIAD). The survey revealed that EIAD has been adopted in 3 of every 4 acute care hospitals, a 4-fold increase since 1993. Of the 74.7% of hospitals reporting EIAD, 64% had written guidelines. Equal or less toxicity (87.1%), equal efficacy (76...

752Assessment of Aminoglycoside Dosing at a Large Academic Medical Center

Background. Intravenous aminoglycoside (AG) dosing is complex and highly individualized based on indication, patient’s age, and renal function. Protocols available at study site guide dosing of AGs. This study assesses adherence to current protocols and investigates efforts needed to optimize AG dosing. Methods. 100 consecutive patients who received AG (gentamicin, tobramycin, or amikacin) from...

Clinical issues surrounding once-daily aminoglycoside dosing in children.

Aminoglycoside antibiotics are first-line treatment for many infectious diseases in the pediatric population and are effective in adults. The traditional dosing interval in children is every 8-12 hours. Studies in adults reported equivalent efficacy and equal or less toxicity with once-daily regimens. Despite many studies in the adult population, this approach has yet to become standard practic...

Idiopathic Granulomatosis Mastitis, Time to a Paradigm Change in Treatment

Idiopathic granulomatous mastitis (IGM) is among the chronic diseases of the breast, which is more common in Middle Eastern countries than in Western countries. Since the etiology of the disease is not well known, there is no international consensus on the management of the disease. Antibiotic, Non-Steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, cytotoxic and immunosuppressive medi...

Modified Aminoglycoside Dosing: An improvement to current practice or a repeat of previous errors?